Comparison of Various Vascular Beds in Man Their Responses to a Simple Vasodilator Stimulus

Comparison of various vascular beds in man; their responses to a simple vasodilator stimulus.

Blood flow to the extremities and kidneys was measured simultaneously in normal subjects, hyper-tensive patients and patients with obliterative arterial disease of the lower extremities. The latter group showed diminished basal flow in the lower extremities, increased basal flow in the upper extremities, and a delayed and diminished response to reflex heating, compared with the normal and hyper...

Effects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways

Objective(s): Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined. The effect of nitric oxide and protein kinase C (PKC) pathways in isolated kidney of Lipopolysaccharide-treated (LPS) rats were investigated in this study. Materials and Methods: Vascular responsiveness to phenylephrine and acetylcholine...

Vasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat.

The effects of 1H-[1,2,4]-oxadizaolo[4,3-]quinoxaline-1-one (ODQ), an inhibitor of the activation of soluble guanylate cyclase (sGC) on responses to NO donors acetylcholine (ACh) and bradykinin (BK) were investigated in the pulmonary and systemic vascular beds of the rat. In these studies the administration of ODQ in a dose of 5 mg/kg iv attenuated vasodilator responses to five different NO don...

Comparison of visceral and peripheral vascular beds in hypertensive patients; their responses to various hypotensive drugs.

Vasomotor responses in the extremities of subjects with various neurologic lesions. I. Reflex responses to warming.

DURING the course of studies concerned with responses of various vascular beds to physiologic and pharmacologic stimuli, it became apparent that the responses evoked in human limbs that had been deprived of their sympathetic innervation were of considerable interest. For purposes of comparison, it seemed advisable to study also the behavior of the vascular response of paralysed extremities in p...